Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

@article{Willner2004ReductionOS,
  title={Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant},
  author={Paul Willner and Anthony Towell and David Sampson and S Sophokleous and Richard Muscat},
  journal={Psychopharmacology},
  year={2004},
  volume={93},
  pages={358-364}
}
Rats exposed chronically (5–9 weeks) to a variety of mild unpredictable stressors showed a reduced consumption of and preference for saccharin or sucrose solutions. Preference deficits took at least 2 weeks to develop and were maintained for more than 2 weeks after termination of the stress regime. Sucrose preference was unaffected by 1 week of treatment with the tricyclic antidepressant DMI but returned to normal after 2–4 weeks of DMI treatment. DMI did not alter sucrose preference in… 

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