Reduction of spectral interferences using ultraclean gold nanowire arrays in the LDI-MS analysis of a model peptide

@article{Colaianni2014ReductionOS,
  title={Reduction of spectral interferences using ultraclean gold nanowire arrays in the LDI-MS analysis of a model peptide},
  author={Louis Colaianni and S. C. Kung and David K. Taggart and Rosaria Anna Picca and John Greaves and Reginald M. Penner and Nicola Cioffi},
  journal={Analytical and Bioanalytical Chemistry},
  year={2014},
  volume={406},
  pages={4571-4583}
}
AbstractThe surface chemistry of gold nanowires (AuNWs) has been systematically assessed in terms of contamination and cleaning processes. The nanomaterial’s surface quality was correlated to its performance in the matrix-free laser desorption ionization mass spectrometry (LDI-MS) analysis of low molecular weight analytes. Arrays of AuNWs were deposited on glass slides by means of the lithographically patterned nanowire electrodeposition technique. AuNWs were then characterized in terms of… 

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References

SHOWING 1-10 OF 51 REFERENCES

Thermally annealed gold nanoparticles for surface-assisted laser desorption ionisation–mass spectrometry of low molecular weight analytes

It was demonstrated that the post-deposition treatments were essential to enhance the AuNP core/analyte interaction, thus resulting in SALDI-MS spectra of significantly improved quality.

Evaluation of Nanoporous Gold with Controlled Surface Structures for Laser Desorption Ionization (LDI) Analysis: Surface Area Versus LDI Signal Intensity

It is shown that the active surface area for solution chemistry can differ from LDI-MS and that NPGs can function as a substrate for LDI oil analysis and that the LDI signal decreased with increasing depth of nanoporous layers, thus increasing the surface area.

Pulsed-laser desorption/ionization of clusters from biofunctional gold nanoparticles: implications for protein detections.

In this paper, we describe a pulsed-laser desorption/ionization mass spectrometry (LDI-MS) approach for the detection of proteins with femtomolar sensitivity through the analysis of gold (Au)

Detailed investigation on the possibility of nanoparticles of various metal elements for surface-assisted laser desorption/ionization mass spectrometry.

Systematic detailed considerations are described of the feasibility of using various metal nanoparticles for organic-matrix-free surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS), and Pt nanoparticles showed the highest performance, owing to their smaller heat conductivity and higher melting temperature.

LDI-MS assisted by chemical-free gold nanoparticles: enhanced sensitivity and reduced background in the low-mass region.

It is shown that chemical-free size selected AuNPs, obtained by laser ablation synthesis in solution (LASiS), have very low background in the low mass region (<500 Da), contrary to citrate stabilized AuNps (citrate-AuNPs) and dihydroxyacetophenone (DHAP).

Nanomaterial-assisted laser desorption ionization for mass spectrometry-based biomedical analysis.

S semiconductor nanomaterials or quantum dots acting as photosensitive centers to induce in-source redox reactions for proteomics and to investigate biomolecule oxidation for metabolomics have been shown to offer new analytical strategies.

Cysteine modified small ligament Au nanoporous film: an easy fabricating and highly efficient surface-assisted laser desorption/ionization substrate.

This work provides a simple and cost-effective route for acquiring an Au nanostructure as a SALDI substrate, which offers a new technique for high-speed analysis of low-molecular weight compounds.

Sensing of oligopeptides using localized surface plasmon resonances combined with Surface-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry.

The ITO plate, which was modified with gold nanorods, was found to be effective in collecting angiotensin molecules adjacent to the gold nan orods, and the SALDI processes that were induced by the photoabsorption of the gold Nanorods efficiently contributed to the desorption and ionization of the ang Elliotensin.
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