Reduction of size of myocardial infarction with nicorandil, a new antianginal drug, after coronary artery occlusion in dogs.

@article{Endo1988ReductionOS,
  title={Reduction of size of myocardial infarction with nicorandil, a new antianginal drug, after coronary artery occlusion in dogs.},
  author={Toyoshi Endo and Jun Nejima and Kaname Kiuchi and Shinichi Fujita and Kenjiro Kikuchi and H. Kikuchi Hayakawa and Hidemasa Okumura},
  journal={Journal of cardiovascular pharmacology},
  year={1988},
  volume={12 5},
  pages={
          587-92
        }
}
The effects of nicorandil, a new antianginal drug, on size of myocardial infarction were studied in anesthetized, open-chest dogs after left anterior descending coronary artery occlusion. To quantify the extent of the hypoperfused zone, 99mTc-albumin microspheres were injected into the left atrium 1 min after occlusion. Fifteen minutes after occlusion, dogs were randomly assigned to a control group or a nicorandil-treated group that received immediately after assignments 100 micrograms/kg of… CONTINUE READING
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