Reduction of respiratory tract binding of benzo[a]pyrene in mice by immunization.

Abstract

Male inbred A/J mice immunized by combined ip and intranasal administration of a bovine serum albumin conjugate of 5-fluoro-12-methylbenzanthryl-7-acetic acid developed tracheal antibodies capable of binding the carcinogen benzo[a]pyrene (BP). Immunized mice administered 92 ng of [3H]BP intranasally exhibited a one-third reduction in BP content in respiratory tract tissues (nose and trachea) when compared with control mice 20 hours after BP administration.

Cite this paper

@article{Moolten1978ReductionOR, title={Reduction of respiratory tract binding of benzo[a]pyrene in mice by immunization.}, author={Frederick L. Moolten and Neva Capparell and Eliahu Boger}, journal={Journal of the National Cancer Institute}, year={1978}, volume={61 5}, pages={1347-9} }