Reduction of respiratory syncytial virus (RSV) in tracheal aspirates in intubated infants by use of humanized monoclonal antibody to RSV F protein.

@article{Malley1998ReductionOR,
  title={Reduction of respiratory syncytial virus (RSV) in tracheal aspirates in intubated infants by use of humanized monoclonal antibody to RSV F protein.},
  author={Richard Malley and John P. Devincenzo and Octavio Ramilo and Penelope H. Dennehy and Hartwig Mei\ssner and William C. Gruber and Pablo J. S{\'a}nchez and Hasan S. Jafri and James Balsley and David S Carlin and Steve C Buckingham and Louis Vernacchio and Donna M. Ambrosino},
  journal={The Journal of infectious diseases},
  year={1998},
  volume={178 6},
  pages={1555-61}
}
Thirty-five children <2 years of age mechanically ventilated for respiratory syncytial virus (RSV) infection were randomized to receive an intravenous infusion of 15 mg/kg MEDI-493 or placebo. RSV concentration was measured in tracheal secretions by plaque assay before and at 24-h intervals after treatment. The reduction in tracheal RSV concentration from day 0 to day 1 (-1.7+/-0.28 vs. -0. 6+/-0.21 log10 pfu/mL; P=.004) and from day 0 to day 2 (-2.5+/-0.26 vs. -1.0+/-0.41 log10 pfu/mL; P=.012… CONTINUE READING