Reduction of reperfusion-induced ventricular fibrillation and infarct size via heme oxygenase-1 overexpression in isolated mouse hearts

@inproceedings{Bak2010ReductionOR,
  title={Reduction of reperfusion-induced ventricular fibrillation and infarct size via heme oxygenase-1 overexpression in isolated mouse hearts},
  author={Istv{\'a}n Bak and Attila Czompa and B{\'e}la Juh{\'a}sz and Istvan Lekli and Arp{\'a}d T{\'o}saki},
  booktitle={Journal of cellular and molecular medicine},
  year={2010}
}
Heme oxygenase-1 (HO-1), also known as heat shock protein 32 (hsp-32) is a stress induced cytoprotective protein. The present investigation evaluated the capacity of HO-1 to reduce the incidence of reperfusion-induced ventricular fibrillation (VF) and infarct size. HO-1 transgenic (Tg) mice were generated using a rat HO-1 genomic transgene. Isolated mouse hearts obtained from Tg and nontransgenic (NTg) groups were exposed to 20 min of global ischemia and 120 min of reperfusion. Epicardial ECG… CONTINUE READING

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