Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation.

  title={Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation.},
  author={Zengshuan Ma and Thanh Hung Nguyen and Thanh Hoa Huynh and Phuc Tien Do and H. Huynh},
  journal={The Journal of endocrinology},
  volume={181 3},
  • Zengshuan Ma, Thanh Hung Nguyen, +2 authors H. Huynh
  • Published 2004
  • Biology, Medicine
  • The Journal of endocrinology
  • Benign prostate hyperplasia and prostate cancer are major public health problems. We report herein that daily treatment of male rats with 50, 100 or 150 mg quercetin per kg body weight resulted in serum concentrations of quercetin equivalent to 25.3 microM, 43.3 microM and 54.3 microM respectively. Concomitantly, serum testosterone levels were increased by 1.79-, 1.83- and 3.48-fold, while serum dihydrotestosterone (DHT) levels were 125%, 92% and 73% of the control. A slight increase in… CONTINUE READING
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