Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humans.

@article{Kok2002ReductionOP,
  title={Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humans.},
  author={Simon W. Kok and Arend Edo Meinders and Sebastiaan Overeem and Gert Jan Lammers and Ferdinand Roelfsema and Marijke Fr{\"o}lich and Hanno Pijl},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 2},
  pages={805-9}
}
Recent observations have implicated hypocretin deficiency in the pathogenesis of narcolepsy. Hypocretin neurotransmission also affects energy balance, and narcoleptic patients tend to become obese. Because hypocretins appear to have important neuroendocrine effects, we hypothesized that the neuroendocrine systems that regulate energy balance might be distinctly set in narcolepsy. As leptin is a pivotal part of these systems, we explored the 24-h plasma leptin (20-min sampling interval… CONTINUE READING