Reduction of plasma angiotensin II to normal levels by antisense oligodeoxynucleotides against liver angiotensinogen cannot completely attenuate vascular remodeling in spontaneously hypertensive rats

@article{Sugano2000ReductionOP,
  title={Reduction of plasma angiotensin II to normal levels by antisense oligodeoxynucleotides against liver angiotensinogen cannot completely attenuate vascular remodeling in spontaneously hypertensive rats},
  author={M. Sugano and K. Tsuchida and S. Sawada and N. Makino},
  journal={Journal of Hypertension},
  year={2000},
  volume={18},
  pages={725–731}
}
  • M. Sugano, K. Tsuchida, +1 author N. Makino
  • Published 2000
  • Medicine
  • Journal of Hypertension
  • Objective The exact role of angiotensinogen (AGT) in vascular remodeling has yet to be determined. In the present study, we examined the effects of reducing plasma AGT by intravenous injections with antisense oligodeoxynucleotides (ODNs) against AGT targeted to the liver on vascular remodeling in spontaneously hypertensive rats (SHRs). Design and methods The ODNs against rat AGT were coupled to asialoglycoprotein (ASOR) carrier molecules, which serve as an important method for regulating liver… CONTINUE READING
    17 Citations
    Increased DNA fragmentation and altered apoptotic protein levels in skeletal muscle of spontaneously hypertensive rats.
    • 29
    • PDF
    eview enin angiotensin aldosterone inhibition in the treatment of ardiovascular disease
    • M. Ferrarioa, Adam E. Mullickb
    • 2017
    • PDF
    Angiotensin Vol. I
    • 3
    Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease
    • 49

    References

    SHOWING 1-10 OF 50 REFERENCES
    Prevention of aortic fibrosis by spironolactone in spontaneously hypertensive rats.
    • 194