Reduction of phenoxyl radicals of the antitumour agent etoposide (VP-16) by glutathione and protein sulfhydryls in human leukaemia cells: Implications for cytotoxicity.

@article{Yalowich1996ReductionOP,
  title={Reduction of phenoxyl radicals of the antitumour agent etoposide (VP-16) by glutathione and protein sulfhydryls in human leukaemia cells: Implications for cytotoxicity.},
  author={Jack C. Yalowich and Yulia Y. Tyurina and Vladimir A. Tyurin and W. P. Allan and Valerian E Kagan},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={1996},
  volume={10 1},
  pages={59-68}
}
Phenoxyl radicals are inevitable intermediates in the oxidative enzymatic metabolism of a phenolic antitumour drug, etoposide (VP-16), by peroxidases, cytochrome P-450, prostaglandin synthetase and tyrosinase, as well as in its interactions with oxygen and peroxyl radicals. It has been shown that one-electron reduction of the VP-16 phenoxyl radical by ascorbate and thiols prevents/delays its oxidative metabolism by tyrosinase both in model systems and in cell homogenates. To elucidate the role… CONTINUE READING

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