Reduction of oxidative stress in amyotrophic lateral sclerosis following pramipexole treatment.

@article{Pattee2003ReductionOO,
  title={Reduction of oxidative stress in amyotrophic lateral sclerosis following pramipexole treatment.},
  author={Gary L. Pattee and Gregory R Post and Rebecca E Gerber and James P. Bennett},
  journal={Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases},
  year={2003},
  volume={4 2},
  pages={90-5}
}
Oxidative abnormalities have been identified both in familial amyotrophic lateral sclerosis (FALS) and the more prevalent sporadic ALS (SALS). Mitochondria dysfunction and toxic free radicals may play a role in this disease process, although the exact pathogenesis of both forms of ALS remains unknown. 2,3-DHBA is a hydroxylated salicylate by product that has been shown to be a reliable marker of increased free radical activity and is reliably assayed by HPLC. Following an oral salicylate load… CONTINUE READING
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