Reduction of oxidative stress and liver injury following silymarin and praziquantel treatment in mice with Mesocestoides vogae (Cestoda) infection.

@article{Velebn2010ReductionOO,
  title={Reduction of oxidative stress and liver injury following silymarin and praziquantel treatment in mice with Mesocestoides vogae (Cestoda) infection.},
  author={Samuel Velebn{\'y} and Gabriela Hr{\vc}kov{\'a} and Al{\vz}beta K{\"o}nigov{\'a}},
  journal={Parasitology international},
  year={2010},
  volume={59 4},
  pages={
          524-31
        }
}
Flavonoid silymarin potentiates antihelmintic effect of praziquantel via down-regulation of oxidative stress and fibrogenesis in the liver
TLDR
In the light of the in vitro findings, silymarin potentiated larvicidal effect of PZQ in the liver indirectly via suppression of oxidative stress and normalisation of GSH redox balance, resulting in the down-regulation of fibrogenesis and consequently in higher availability of drug for parasite.
Differential Effects of the Flavonolignans Silybin, Silychristin and 2,3-Dehydrosilybin on Mesocestoides vogae Larvae (Cestoda) under Hypoxic and Aerobic In Vitro Conditions
TLDR
SB and SCH suppressed mitochondrial functions and energy stores, inducing a physiological misbalance, whereas DHSB exhibited a direct larvicidal effect due to damage to the tegument and complete disruption of larval physiology and metabolism.
Investigating in vitro anti-leishmanial effects of silibinin and silymarin on Leishmania major
TLDR
It is demonstrated that both medications have suitable effects like Glucantime® on the parasite in vitro and clinical assessment of the anti-leishmanial activity of silibinin and silymarin for treating the dermal lesions caused by L. major is recommended.
Natural Compounds Exerting Anthelmintic and/or Host-Protecting Effects During Parasitic Infections
TLDR
In this chapter, after a brief introduction to key features of immunosuppression and host pathology, anthelmintic and immunomodulatory activities of artemisinins, genistein, curcumin, and tannins are described with some insight into selective toxicity to pathogens and cancer cells, but very low toxicity to the normal cells in the hosts.
Silymarin inhibits cisplatin-mediated apoptosis via inhibition of hydrogen peroxide and hydroxyl radical generation
TLDR
It is demonstrated that silymarin could attenuate hydrogen peroxide and hydroxyl radical generated by cisplatin while having minimal effect on superoxide anion level and could be beneficial for the development of this compound as a combination therapy in patients before receiving cisPlatin.
Differential Sensitivity of Myeloid and Lymphoid Cell Populations to Apoptosis in Peritoneal Cavity of Mice with Model Larval Mesocestoides Vogae Infection
TLDR
The kinetic of myeloid and lymphoid cell populations and the proportions of cells undergoing apoptosis in peritoneal cavities of mice within the first month after oral infection with M. vogae infection were investigated, suggesting their important role in the host-parasite interactions.
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References

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Impact of treatment with praziquantel, silymarin and/or β-glucan on pathophysiological markers of liver damage and fibrosis in mice infected with Mesocestoides vogae (Cestoda) tetrathyridia
TLDR
Combined treatment of PZQ with silymarin and/or β-glucan was able to ameliorate or suppress fibrogenesis in the liver, protect liver cells from oxidative damage and, possibly, stimulate regeneration of the parenchyma.
Praziquantel and liposomized glucan-treatment modulated liver fibrogenesis and mastocytosis in mice infected with Mesocestoides vogae (M. corti, Cestoda) tetrathyridia
TLDR
The pattern of cell proliferation indicates that in the case of PZQ treatment, the reparative processes of liver parenchyma are enhanced in an inverse correlation with the intensity of infection.
Increased 4‐hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis
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Dissociation between the initiation of alcoholic liver necrosis and enhanced lipid peroxidation is demonstrated, association of enhanced lipidPeroxidation with liver fibrogenesis and depressed antioxidant system is association, and the first demonstration of increased 4‐hydroxynonenal level in experimental alcoholic liver disease is demonstrated.
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TLDR
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TLDR
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