Reduction of nucleosome assembly during new DNA synthesis impairs both major pathways of double-strand break repair

@article{Lewis2005ReductionON,
  title={Reduction of nucleosome assembly during new DNA synthesis impairs both major pathways of double-strand break repair},
  author={London H. K. Lewis and Gopalakrishnan Karthikeyan and Jared Cassiano and Michael A. Resnick},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={4928 - 4939}
}
Assembly of new chromatin during S phase requires the histone chaperone complexes CAF-1 (Cac2p, Msi1p and Rlf2p) and RCAF (Asf1p plus acetylated histones H3 and H4). Cells lacking CAF-1 and RCAF are hypersensitive to DNA-damaging agents, such as methyl methanesulfonate and camptothecin, suggesting a possible defect in double-strand break (DSB) repair. Assays developed to quantitate repair of defined, cohesive-ended break structures revealed that DSB-induced plasmid:chromosome recombination was… CONTINUE READING

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Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells

  • L. K. Lewis, F. Storici, S. Van Komen, S. Calero, P. Sung, M. A. Resnick
  • Genetics
  • 2004

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