Reduction of nitric oxide level enhances the radiosensitivity of hypoxic non-small cell lung cancer.

@article{Saleem2011ReductionON,
  title={Reduction of nitric oxide level enhances the radiosensitivity of hypoxic non-small cell lung cancer.},
  author={Wael Saleem and Yoshiyuki Suzuki and Abdulelah Mobaraki and Yukari Yoshida and Shinei Noda and Jun-ich Saitoh and Takashi Nakano},
  journal={Cancer science},
  year={2011},
  volume={102 12},
  pages={2150-6}
}
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (E-TKI) resistance has emerged as an important clinical issue. To overcome this resistance, researchers have examined different modalities, either for use as a monotherapy or in combination with E-TKI therapy. In the present study, we investigated whether a decrease in nitric oxide (NO) levels affects the radiosensitization of non-small cell lung cancer (NSCLC) cell lines. A549 and H3255 NSCLC cells were examined. They were… CONTINUE READING
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