Reduction of nicotinamide adenine dinucleotide levels by ultimate carcinogens in human lymphocytes.

@article{Rankin1980ReductionON,
  title={Reduction of nicotinamide adenine dinucleotide levels by ultimate carcinogens in human lymphocytes.},
  author={Patrick W. Rankin and M. Kristin Jacobson and V. Mitchell and David L. Busbee},
  journal={Cancer research},
  year={1980},
  volume={40 6},
  pages={
          1803-7
        }
}
The effect of several classes of DNA-damaging chemicals and closely related compounds on cellular nicotinamide adenine dinucleotide (NAD) levels was studied in freshly isolated peripheral human lymphocytes. Of the 21 compounds examined, 7 were direct DNA-damaging agents and 14 were non-DNA-damaging compounds or required metabolic activation to casue DNA damage. Rapid lowering of cellular NAD levels was caused by each of the direct DNA-damaging chemicals examined in this study including N-methyl… CONTINUE READING

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