Reduction of neural adhesions by biodegradable autocrosslinked hyaluronic acid gel after injury of peripheral nerves: an experimental study.

@article{Smit2004ReductionON,
  title={Reduction of neural adhesions by biodegradable autocrosslinked hyaluronic acid gel after injury of peripheral nerves: an experimental study.},
  author={Xander Smit and Johan Wilhelm Van Neck and Andrew Afoke and Steven E. R. Hovius},
  journal={Journal of neurosurgery},
  year={2004},
  volume={101 4},
  pages={648-52}
}
OBJECT Adhesion formation is a serious problem in peripheral nerve surgery, frequently causing dysfunction and pain. The authors aimed to develop an objective biomechanical method of quantifying nerve adhesions and to use this technique for the evaluation of the efficacy of an autocrosslinked hyaluronic acid (HA) gel as an antiadhesion therapy. METHODS Thirty-three female Wistar rats underwent dissection, crush injury, or transection plus repair of the sciatic nerve. The nerves were or were… CONTINUE READING