Reduction of myofibrillar ATPase activity and isomyosin shift in delayed doxorubicin cardiotoxicity.

@article{Cappelli1989ReductionOM,
  title={Reduction of myofibrillar ATPase activity and isomyosin shift in delayed doxorubicin cardiotoxicity.},
  author={Valeria Cappelli and Richard A. Moggio and Elena Monti and Luisa Paracchini and Franco Piccinini and Carlo Reggiani},
  journal={Journal of molecular and cellular cardiology},
  year={1989},
  volume={21 1},
  pages={93-101}
}
The aim of this study was to determine whether variations of isomyosin expression occurred during doxorubicin-induced cardiomyopathy. A suitable experimental model in which pure delayed cardiotoxic effects could be easily studied was adopted. Young adult female Sprague Dawley rats received 9 mg/kg of doxorubicin (DXR) i.v. divided into three subdoses of 3 mg/kg every third day. Control animals received equal volumes of saline. The animals were examined 9 weeks after treatment. At this time the… CONTINUE READING
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