Reduction of myocardial infarction by calpain inhibitors A-705239 and A-705253 in isolated perfused rabbit hearts.

@article{Neuhof2004ReductionOM,
  title={Reduction of myocardial infarction by calpain inhibitors A-705239 and A-705253 in isolated perfused rabbit hearts.},
  author={Christiane Neuhof and Verena Fabiunke and Karin Deibele and Maria Speth and Achim M{\"o}ller and Wilfried Lubisch and Hans Fritz and Harald Tillmanns and Heinz Neuhof},
  journal={Biological chemistry},
  year={2004},
  volume={385 11},
  pages={1077-82}
}
Two novel calpain inhibitors (A-705239 and A-705253) were studied in isolated perfused rabbit hearts subjected to 60-min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first diagonal branch), followed by 120 min of reperfusion. The inhibitors were added to the perfusion fluid in various final concentrations… CONTINUE READING