Reduction of myoblast differentiation following multiple population doublings in mouse C2 C12 cells: a model to investigate ageing?

@article{Sharples2011ReductionOM,
  title={Reduction of myoblast differentiation following multiple population doublings in mouse C2 C12 cells: a model to investigate ageing?},
  author={Adam P Sharples and Nasser Al-Shanti and Mark P Lewis and Claire Elizabeth Stewart},
  journal={Journal of cellular biochemistry},
  year={2011},
  volume={112 12},
  pages={3773-85}
}
Ageing skeletal muscle displays declines in size, strength, and functional capacity. Given the acknowledged role that the systemic environment plays in reduced regeneration (Conboy et al. [2005] Nature 433: 760-764), the role of resident satellite cells (termed myoblasts upon activation) is relatively dismissed, where, multiple cellular divisions in-vivo throughout the lifespan could also impact on muscular deterioration. Using a model of multiple population doublings (MPD) in-vitro thus… CONTINUE READING