Reduction of mouse egg surface integrin alpha9 subunit (ITGA9) reduces the egg's ability to support sperm-egg binding and fusion.

@article{Vjugina2009ReductionOM,
  title={Reduction of mouse egg surface integrin alpha9 subunit (ITGA9) reduces the egg's ability to support sperm-egg binding and fusion.},
  author={Ulyana Vjugina and Xiaoling Zhu and Eugene Oh and Nabal Jose Bracero and Janice P. Evans},
  journal={Biology of reproduction},
  year={2009},
  volume={80 4},
  pages={
          833-41
        }
}
The involvement of egg integrins in mammalian sperm-egg interactions has been controversial, with data from integrin inhibitor studies contrasting with evidence from knockouts showing that specific integrin subunits are not essential for fertility. An alpha(4)/alpha(9) (ITGA4/ITGA9) integrin subfamily member has been implicated in fertilization but not extensively examined, so we tested the following three hypotheses: 1) an ITGA4/ITGA9 integrin participates in sperm-egg interactions, 2) short… CONTINUE READING
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