Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit.

Abstract

Forming the structure of the human brain involves extensive neuronal migration, a process dependent on cytoskeletal rearrangement. Neuronal migration is believed to be disrupted in patients exhibiting the developmental brain malformation lissencephaly. Previous studies have shown that LIS1, the defective gene found in patients with lissencephaly, is a… (More)

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