Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue.

  title={Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue.},
  author={Stephen A Schnell and William Alan Staines and Martin W Wessendorf},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  volume={47 6},
The fluorescent pigment lipofuscin accumulates with age in the cytoplasm of cells of the CNS. Because of its broad excitation and emission spectra, the presence of lipofuscin-like autofluorescence complicates the use of fluorescence microscopy (e.g., fluorescent retrograde tract tracing and fluorescence immunocytochemistry). In this study we examined several chemical treatments of tissue sections for their ability to reduce or eliminate lipofuscin-like autofluorescence without adversely… CONTINUE READING
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