Reduction of ischemic brain damage and increase of glutathione by a liposomal preparation of quercetin in permanent focal ischemia in rats

@article{Rivera2008ReductionOI,
  title={Reduction of ischemic brain damage and increase of glutathione by a liposomal preparation of quercetin in permanent focal ischemia in rats},
  author={Francisca Rivera and Gustavo Trevisan Costa and Andr{\'e}s Abin and Jessika Urbanavicius and Cristina Arruti and Gabriela Amorim Casanova and Federico Dajas},
  journal={Neurotoxicity Research},
  year={2008},
  volume={13},
  pages={105-114}
}
Oxidative stress is implicated in the pathogenesis of cerebral ischemia injury, and the flavonoids have shown to be neuroprotective in experimental models of cerebral ischemia. Previously, we have shown that an aqueous preparation of quercetin did not reach the brain while a liposomal preparation produced measurable cerebral amounts of quercetin that reduced significantly the cerebral damage provoked by permanent middle cerebral artery occlusion (pMCAo) of rats.In this context, the protective… CONTINUE READING
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SHOWING 1-10 OF 52 REFERENCES

Ischemic cell death in brain neurons.

  • Physiological reviews
  • 1999
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Neuroproteciton by flavonoids

F Dajas
  • Braz . J . Med . Biol . Res .
  • 2003

Histochemical analysis of plasma membrane calcium-ATPase activity in hippocampal CA1 pyramidal neurons following transient forebrain ischemia

JR RW Frederick
  • Neumar
  • 2001