Reduction of ischemic K+ loss and arrhythmias in rat hearts. Effect of glibenclamide, a sulfonylurea.

@article{Kantor1990ReductionOI,
  title={Reduction of ischemic K+ loss and arrhythmias in rat hearts. Effect of glibenclamide, a sulfonylurea.},
  author={Paul Fraser Kantor and William A Coetzee and Edward E. Carmeliet and Steven C. Dennis and Lionel Henry Opie},
  journal={Circulation research},
  year={1990},
  volume={66 2},
  pages={478-85}
}
Glibenclamide, one of the antidiabetic sulfonylureas, is known to block ATP-dependent K+ channels. We used this drug to determine to what extent K+ loss from acutely ischemic myocardium is mediated via these channels. We also investigated whether glibenclamide would influence ischemic arrhythmias. Isolated rat hearts rendered globally ischemic showed no correlation between early lactate and K+ efflux rates. Cumulative K+ loss during 11 minutes of global ischemia (0.5 ml min-1 g-1) was reduced… CONTINUE READING
78 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 78 extracted citations

Similar Papers

Loading similar papers…