Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase.

@article{Waki2001ReductionOI,
  title={Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase.},
  author={Mitsunori Waki and Yusuke Yoshida and Takayuki Oka and Mitsuyoshi Azuma},
  journal={Current eye research},
  year={2001},
  volume={22 6},
  pages={470-4}
}
PURPOSE Rho-associated coiled coil-forming protein kinase (ROCK) is a downstream target of a small GTPase, Rho. The kinase has been reported to regulate actomyosin-based contractility of smooth muscles by modulation of myosin phosphatase activity. Contractility of ciliary muscle could be implicated in regulation of intraocular pressure while that of ocular vessels could affect blood flow to retina. The present study has been performed to investigate the effect of a ROCK inhibitor on intraocular… CONTINUE READING

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