Reduction of intracellular calcium removal rate can explain changes in seizure dynamics: studies in neuronal network models.

@article{Kudela2003ReductionOI,
  title={Reduction of intracellular calcium removal rate can explain changes in seizure dynamics: studies in neuronal network models.},
  author={Pawel Kudela and Piotr J. Franaszczuk and Gregory K. Bergey},
  journal={Epilepsy research},
  year={2003},
  volume={57 2-3},
  pages={95-109}
}
Complex partial seizures originating from mesial temporal structures are characterized by relatively short durations of organized rhythmic activity (ORA) of 5-8 Hz, typically lasting less than 60s. Previous investigations into seizure dynamics have revealed that this ORA undergoes a monotonic decline prior to seizure evolution into intermittent bursting and subsequent seizure termination. Large neural network models of simplified single-compartment neurons were employed to address the… CONTINUE READING

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