Reduction of intimal hyperplasia by naroparcil, a 4-methylumbelliferyl beta-D-xyloside analogue, after arterial injury in the hypercholesterolemic rabbit.

  title={Reduction of intimal hyperplasia by naroparcil, a 4-methylumbelliferyl beta-D-xyloside analogue, after arterial injury in the hypercholesterolemic rabbit.},
  author={Ph. Gabriel Steg and Marianne Ziol and O. Tahlil and C Robert and Philippe Masson and Didier Pruneau and Patrick Bruneval and Pierre B{\'e}lichard},
  journal={Circulation research},
  volume={77 5},
4-Methylumbelliferyl beta-D-xylosides (beta-D-xylosides) inhibit proteoglycan synthesis, and this is associated with reduced proliferation and extracellular matrix production by vascular smooth muscle cells. This study evaluated whether treatment with naroparcil, a beta-D-xyloside analogue, reduced intimal hyperplasia after arterial injury in the hypercholesterolemic rabbit. Forty-two rabbits were assigned to three groups that received either a 1% cholesterol-enriched diet (group 1, n = 15) or… Expand
The perspective in this book chapter is on the role of matrix proteins in the restenotic process, which appears to be an integral part of the vascular response to injury in the intima and probably in the adventitia as well. Expand
Drug‐Mediated Regulation of Glycosaminoglycan Biosynthesis
  • G. Ghiselli
  • Medicine, Biology
  • Medicinal research reviews
  • 2017
This review article proposes a classification scheme for drugs affecting GAG biosynthesis and presents a rational approach to investigate the pharmacological regulation of these important biological molecules. Expand
Irradiation inhibits vascular anastomotic stenosis in a canine model
Irradiation can inhibit anastomotic stenosis in a canine model and appears to target the adventitia, which is a factor in the creation of stenosis. Expand
Determination of endogenous glycosaminoglycans derived disaccharides in human plasma by HPLC: validation and application in a clinical study.
The present method has been used to investigate the GAGs levels in the plasma of patients in a phase II clinical study of SB-424323 and is simple, reliable, and easily adaptable to analysis of large number of samples under logistics of a clinical study. Expand
Preconditioning of salvaged myocardium in conscious rabbits with postinfarction dysfunction.
Multiple cycles of PC induced an almost complete protection against postinfarction dysfunction, potentially involving beneficial effects on salvaged myocardium. Expand
The extracellular matrix in balloon arterial injury: a novel target for restenosis prevention.
The structure and function of vascular ECM and the importance of the matrix in modulating the vascular response to arterial injury such as balloon angioplasty and atherosclerosis are reviewed. Expand
Concise synthesis of 6-sulfonylated 3,4-dihydro-2h-thiopyrans and 7-sulfonylated 3,4,5,6-tetrahydrothiepines from lactols
A concise method for the synthesis of the title compounds has been developed, which involves condensation of lactols with methylthiomethyl p-tolyl sulfone, followed by mesylation and furtherExpand


The effect of the beta-D-xyloside naroparcil on circulating plasma glycosaminoglycans. An explanation for its known antithrombotic activity in the rabbit.
This is, to the authors' knowledge, the first description of the in vivo effect of a beta-D-xyloside on GAG biosynthesis and this is correlated with an antithrombotic action. Expand
Alpha- and beta-xylosides modulate the synthesis of fibronectin and thrombospondin-1 by endothelial cells.
It is suggested that the inhibition of endothelial morphogenesis by xylosides may be due to the actions of these compounds on the synthesis of specific proteins. Expand
The effect of beta-D-xylosides on the proliferation and proteoglycan biosynthesis of monoblastic U-937 cells.
The inhibition of proliferation observed in the presence of 1 mM-HX-xyl did not lead to differentiation of the cells into macrophage-like cells, as is observed when the cells are cultured in the absence of phorbol esters, agents also known to inhibit proliferation of U-937 cells. Expand
The venous antithrombotic profile of naroparcil in the rabbit.
The venous antithrombotic profile of naroparcil or (4-[4-cyanobenzoyl]-phenyl)-1.5-dithio-beta-D-xylopyranoside was investigated in the rabbit following single i.v. and oral administration and thrombin generation by the intrinsic pathway was reduced in a dose-related manner. Expand
Alpha- and beta-xylosides alter glycolipid synthesis in human melanoma and Chinese hamster ovary cells.
It is found that when human melanoma cells and Chinese hamster ovary cells are labeled with [3H] galactose in the presence of 4-methyl umbelliferyl beta-D-xyloside (Xyl beta 4MU), a large portion of the labeled acceptor does not consist of the expected GAG chains, but of the novel GM3 ganglioside-like structure. Expand
Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis.
Significant increases in collagen, elastin, and proteoglycan synthesis, up to 4 to 10 times above control nondamaged contralateral iliac arteries, were noted at 1, 2, and 4 weeks, accompanied by significant increases in synthesis that coincided with the temporal increase in cross-sectional area. Expand
The effect of beta-xylosides on heparan sulfate synthesis by SV40-transformed Swiss mouse 3T3 cells.
The covalent association of the beta-xyloside to theMedium heparan sulfate produced by cells grown in the presence of [35S]sulfate and the fluorogenic beta-Xylosides, 4-methylumbelliferyl-beta-D-xyoside was demonstrated. Expand
Co-localization of aortic apolipoprotein B and chondroitin sulfate in an injury model of atherosclerosis.
The close spatial relation between CS-PG and apo B inside the aortic lesions seems to support the hypothesis of their in situ interaction and of a simultaneous cellular uptake, and may be related to the development of both extracellular lipid deposits and the formation of FCs in atherogenesis. Expand
Altered proteoglycan synthesis via the false acceptor pathway can be dissociated from beta-D-xyloside inhibition of proliferation.
Results indicate that the perturbation of PG synthesis via the false acceptor pathway can be uncoupled from control of cell proliferation. Expand
Effect of vitamin E on vascular integrity in cholesterol-fed guinea pigs.
It is suggested that vitamin E preserves the morphological and functional integrity of the vascular wall and may contribute to the inhibition of atherogenesis in cholesterol-fed guinea pigs. Expand