Reduction of intimal hyperplasia by naroparcil, a 4-methylumbelliferyl beta-D-xyloside analogue, after arterial injury in the hypercholesterolemic rabbit.

@article{Steg1995ReductionOI,
  title={Reduction of intimal hyperplasia by naroparcil, a 4-methylumbelliferyl beta-D-xyloside analogue, after arterial injury in the hypercholesterolemic rabbit.},
  author={Ph. Gabriel Steg and Marianne Ziol and O. Tahlil and C Robert and Philippe Masson and Didier Pruneau and Patrick Bruneval and Pierre B{\'e}lichard},
  journal={Circulation research},
  year={1995},
  volume={77 5},
  pages={
          919-26
        }
}
4-Methylumbelliferyl beta-D-xylosides (beta-D-xylosides) inhibit proteoglycan synthesis, and this is associated with reduced proliferation and extracellular matrix production by vascular smooth muscle cells. This study evaluated whether treatment with naroparcil, a beta-D-xyloside analogue, reduced intimal hyperplasia after arterial injury in the hypercholesterolemic rabbit. Forty-two rabbits were assigned to three groups that received either a 1% cholesterol-enriched diet (group 1, n = 15) or… Expand
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