Reduction of infarct size by the NO donors sodium nitroprusside and spermine/NO after transient focal cerebral ischemia in rats.

@article{Salom2000ReductionOI,
  title={Reduction of infarct size by the NO donors sodium nitroprusside and spermine/NO after transient focal cerebral ischemia in rats.},
  author={Juan B. Salom and Marta Ort{\'i} and Jos{\'e} M. Centeno and Germ{\'a}n Torregrosa and Enrique Alborch},
  journal={Brain research},
  year={2000},
  volume={865 2},
  pages={149-56}
}
Nitric oxide (NO) plays a dual role (neuroprotection and neurotoxicity) in cerebral ischemia. NO promoting strategies may be beneficial shortly after ischemia. Therefore, we have studied the hemodynamic and possible neuroprotective effects of two NO donors, the classical nitrovasodilator sodium nitroprusside (SNP) and the NONOate spermine/NO, after transient focal cerebral ischemia in rats. Parietal cortical perfusion was measured by laser-Doppler flowmetry. The effects of increasing… CONTINUE READING

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