Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA.

@article{Barandon2003ReductionOI,
  title={Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA.},
  author={Laurent Barandon and Thierry Couffinhal and J{\'e}r{\^o}me Ezan and Pascale Dufourcq and Pierre Costet and Philippe Alzieu and Lionel Leroux and Catherine Moreau and Dani{\`e}le Dare and Cecile Duplaa},
  journal={Circulation},
  year={2003},
  volume={108 18},
  pages={
          2282-9
        }
}
BACKGROUND FrzA/sFRP-1, a secreted, frizzled-related protein and antagonist for the wnt/frizzled pathway, is expressed in the heart and vessels during mouse embryogenesis and adulthood. FrzA is involved in cell cycle control of vascular cells and angiogenesis. We assessed the hypothesis that FrzA could control the healing process after myocardial infarction (MI). METHODS AND RESULTS We demonstrated an upregulation of sFRP-1 and distinct wnt and fz member expression after MI. We established… CONTINUE READING

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