Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway.

@article{Tostar2010ReductionOH,
  title={Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway.},
  author={Ulrica Tostar and Rune Toftg{\aa}rd and Peter G. Zaphiropoulos and Takashi Shimokawa},
  journal={Genes & cancer},
  year={2010},
  volume={1 9},
  pages={941-51}
}
Rhabdomyosarcoma (RMS) is the most frequent soft-tissue sarcoma in children. Embryonal rhabdomyosarcoma (E-RMS) represents the most common RMS subtype, but the molecular events driving this tumor are still largely unknown. The hedgehog (HH) pathway, a major signal transduction cascade, is linked with many cancers, including RMS. As we previously have detected loss of heterozygosity of PTCH1 in E-RMS, we now examined 8 E-RMS tumor samples and 5 E-RMS cell lines for the presence of PTCH1… CONTINUE READING
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