Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide.

@article{Imai2007ReductionOH,
  title={Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide.},
  author={Yumi N. Imai and Gladys M Varela and Malaka B. Jackson and Mark J. Graham and Rosanne M. Crooke and Rexford S. Ahima},
  journal={Gastroenterology},
  year={2007},
  volume={132 5},
  pages={1947-54}
}
BACKGROUND & AIMS Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive triglyceride accumulation in hepatocytes. Expression of the lipid droplet protein adipose differentiation-related protein (ADRP) is increased in NAFLD, but whether this is causally linked to hepatic lipid metabolism is unclear. We postulated that a reduction in ADRP would ameliorate hepatic steatosis and improve insulin action. METHODS Leptin deficient Lep(ob/ob) and diet-induced obese (DIO) mice were… CONTINUE READING