Reduction of hepatitis C virus NS5A phosphorylation through its interaction with amphiphysin II.

@article{Masumi2005ReductionOH,
  title={Reduction of hepatitis C virus NS5A phosphorylation through its interaction with amphiphysin II.},
  author={Atsuko Masumi and Hideki Aizaki and Tetsuro Suzuki and James B DuHadaway and George C Prendergast and Katsutoshi Komuro and Hidesuke Fukazawa},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={336 2},
  pages={572-8}
}
Hepatitis C virus non-structural protein 5A (NS5A) is a pleiotropic protein with key roles in viral RNA replication, modulation of cellular-signaling pathways and interferon (IFN) responses. To search for possible host factors involved in mediating these functions of NS5A, we adopted an affinity purification approach coupled with mass spectrometry to examine protein-protein interactions, and found that human amphiphysin II (also referred to as Bin1) specifically interacts with NS5A in mammalian… CONTINUE READING

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