Reduction of hepatic ischemia/reperfusion injury by a soluble P-selectin glycoprotein ligand-1.

@article{Dulkanchainun1998ReductionOH,
  title={Reduction of hepatic ischemia/reperfusion injury by a soluble P-selectin glycoprotein ligand-1.},
  author={T S Dulkanchainun and John Alan Goss and David K. Imagawa and Gray D. Shaw and Dean M. Anselmo and Fady M. Kaldas and T Y Wang and Delai Zhao and Ashley Busuttil and Hirohisa Kato and Natalie G B Murray and Jerzy W. Kupiec-Weglinski and Ronald W Busuttil},
  journal={Annals of surgery},
  year={1998},
  volume={227 6},
  pages={832-40}
}
OBJECTIVE The authors' goal was to determine the effects of specific binding and blockade of P- and E-selectins by a soluble P-selectin glycoprotein ligand-1 (PSGL-1) in rat models of hepatic in vivo warm ischemia and ex vivo cold ischemia. The authors also sought to determine the effect of selectin blockade on isograft survival in a syngeneic rat orthotopic liver transplant model. SUMMARY BACKGROUND DATA Ischemia/reperfusion (I/R) injury is a major factor in poor graft function after liver… CONTINUE READING