Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans.

@article{Meier2007ReductionOH,
  title={Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans.},
  author={Juris J Meier and Jens Juul Holst and Wolfgang Schmidt and Michael A Nauck},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={293 3},
  pages={E849-56}
}
Changes in hepatic insulin clearance can occur after oral glucose or meal ingestion. This has been attributed to the secretion and action of gastric inhibitory polypeptide (GIP) and glucagon-like peptide (GLP)-1. Given the recent availability of drugs based on incretin hormones, such clearance effects may be important for the future treatment of type 2 diabetes. Therefore, we determined insulin clearance in response to endogenously secreted and exogenously administered GIP and GLP-1. Insulin… CONTINUE READING

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