Reduction of glutamatergic neurotransmission by prolonged exposure to dieldrin involves NMDA receptor internalization and metabotropic glutamate receptor 5 downregulation.

@article{Briz2010ReductionOG,
  title={Reduction of glutamatergic neurotransmission by prolonged exposure to dieldrin involves NMDA receptor internalization and metabotropic glutamate receptor 5 downregulation.},
  author={V{\'i}ctor Briz and Mireia Galofr{\'e} and Cristina Su{\~n}ol},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2010},
  volume={113 1},
  pages={
          138-49
        }
}
Dieldrin was previously used as a pesticide. Although its use has been discontinued, humans are still exposed to it due to its high environmental persistence and because it accumulates in the adipose tissue of animals. Acute exposure to dieldrin provokes convulsions due to its antagonism on the gamma-aminobutyric acid-A (GABA(A)) receptor. However, little is known about the effects of low chronic exposure to this pollutant. In the present work, we use primary cultures of cortical neurons to… CONTINUE READING

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