Reduction of experimental myocardial infarct size with hyperosmolar mannitol.

@article{Kloner1976ReductionOE,
  title={Reduction of experimental myocardial infarct size with hyperosmolar mannitol.},
  author={Robert A. Kloner and Keith A. Reimer and James T. Willerson and Robert B. Jennings},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1976},
  volume={151 4},
  pages={677-83}
}
Hypertonic mannitol previously has been shown to improve cardiac function, increase collateral flow, and decrease epicardial ST segment elevation following coronary occlusion in anesthetized or awake dogs. The present study quantitates by morphologic techniques, the effect of hypertonic mannitol on infarct size. Ischemic injury was produced by proximal occlusion of the circumflex artery for 40 min and necrosis was assessed after 48 hr of reflow. One group of dogs was given isotonic saline and… CONTINUE READING
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