Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta.

@article{Whittle2006ReductionOE,
  title={Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta.},
  author={Brendan J. R. Whittle and Csaba Varga and Anik{\'o} P{\'o}sa and Andor Moln{\'a}r and Marika Collin and Christoph Thiemermann},
  journal={British journal of pharmacology},
  year={2006},
  volume={147 5},
  pages={575-82}
}
The effects of the inhibitors of glycogen synthase kinase-3beta (GSK-3beta), TDZD-8 and SB 415286, which can substantially reduce the systemic inflammation associated with endotoxic shock in vivo, have now been investigated on the acute colitis provoked by trinitrobenzene sulphonic acid (TNBS) in the rat. Administration of the GSK-3beta inhibitor TDZD-8 (0.1, 0.33 or 1.0 mg kg-1, s.c., b.i.d., for 3 days) caused a dose-dependent reduction in the colonic inflammation induced by intracolonic TNBS… CONTINUE READING
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