Reduction of excessive alcohol drinking by a novel GABAB receptor positive allosteric modulator ADX71441 in mice

@article{Hwa2013ReductionOE,
  title={Reduction of excessive alcohol drinking by a novel GABAB receptor positive allosteric modulator ADX71441 in mice},
  author={Lara S. Hwa and Mikhail Kalinichev and Hasna{\'a} Haddouk and Sonia Maria Poli and Klaus A Miczek},
  journal={Psychopharmacology},
  year={2013},
  volume={231},
  pages={333-343}
}
RationaleA promising pharmacotherapy for alcohol use disorders has been positive allosteric modulators (PAMs) of the γ-aminobutyric acid receptor B (GABAB R) since GABAB R PAMs reduce ethanol drinking and self-administration in rodents.ObjectiveThe current studies investigated a novel, selective GABAB R PAM, ADX71441, in comparison to naltrexone in a protocol of ethanol binge-like drinking, drinking-in-the-dark (DID), and in a model of long-term, excessive drinking, intermittent access to… CONTINUE READING
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