Reduction of eosinophilic inflammation in the airways of patients with asthma using montelukast.

@article{Minoguchi2002ReductionOE,
  title={Reduction of eosinophilic inflammation in the airways of patients with asthma using montelukast.},
  author={Kenji Minoguchi and Yasurou Kohno and Hideko Minoguchi and Norio Kihara and Yasuyuki Sano and Hajime Yasuhara and Mitsuru Adachi},
  journal={Chest},
  year={2002},
  volume={121 3},
  pages={732-8}
}
OBJECTIVE Leukotrienes (LTs) are involved in airway eosinophilic inflammation in patients with asthma. We examined the effects of a cysteinyl LT 1-receptor antagonist, montelukast, on sputum eosinophil levels, and the correlation between sputum eosinophils and bronchodilatation in patients with asthma. DESIGN Double-blind, randomized, crossover study. SETTING University hospital and private hospital. PATIENTS Twenty-nine patients with mild-to-moderate asthma. INTERVENTIONS Montelukast… CONTINUE READING

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