Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model

@inproceedings{Douhara2015ReductionOE,
  title={Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model},
  author={Akitoshi Douhara and Kei Moriya and Hitoshi Yoshiji and Ryuichi Noguchi and Tadashi Namisaki and Mitsuteru Kitade and Kosuke Kaji and Yosuke Aihara and Norihisa Nishimura and Kosuke Takeda and Yasushi Okura and Hideto Kawaratani and Hiroshi Fukui},
  booktitle={Molecular medicine reports},
  year={2015}
}
Previous clinical studies have demonstrated that endotoxin/toll‑like receptor 4 (TLR4) signaling is critical in the inflammatory pathways associated with non‑alcoholic steatohepatitis (NASH). In human and animal studies, NASH was associated with portal lipopolysaccharide (LPS) and the plasma LPS level was hypothesized to be associated with small intestinal bacterial overgrowth, change in composition of the microbiota and increased intestinal permeability. The aim of the present study was to… CONTINUE READING

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