Reduction of eicosanoid production by essential fatty acid depletion does not attenuate the inflammatory response induced by Pseudomonas aeruginosa pneumonia in rat lung.

@article{OSullivan1992ReductionOE,
  title={Reduction of eicosanoid production by essential fatty acid depletion does not attenuate the inflammatory response induced by Pseudomonas aeruginosa pneumonia in rat lung.},
  author={Bernadine O'Sullivan and S Mong and Bartholomew J. Votta and Daniel V. Schidlow},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={1992},
  volume={46 3},
  pages={
          203-10
        }
}
Sipid mediators of inflammation have been implicated in the pathogenesis of Pseudomonas aeruginosa (PA) related pulmonary damage in patients with cystic fibrosis. We studied the role of these mediators in a rat model of PA endobronchitis using essential fatty acid deficient (EFAD) animals. Whole blood from EFAD animals produced significantly less leukotriene B4 (LTB4) and hydroxyheptadecatrienoic acid when stimulated ex vivo than did whole blood from control animals (p less than 0.005… CONTINUE READING