Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia.

  title={Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia.},
  author={David Brown and Sharon L. Hale and Christopher P. Baines and Carlos L. del Rio and Robert Louis Hamlin and Yukie Yueyama and Anusak Kijtawornrat and Steve Yeh and Chad R. Frasier and Luke M. Stewart and Fatiha Moukdar and Saame Raza Shaikh and Kelsey H. Fisher-Wellman and P. Darrell Neufer and Robert A. Kloner},
  journal={Journal of cardiovascular pharmacology and therapeutics},
  volume={19 1},
We recently showed that Bendavia, a novel mitochondria-targeting peptide, reduced infarction and no-reflow across several experimental models. The purpose of this study was to determine the therapeutic timing and mechanism of action that underlie Bendavia's cytoprotective property. In rabbits exposed to in vivo ischemia/reperfusion (30/180 min), Bendavia administered 20 minutes prior to reperfusion (0.05 mg/kg/h, intravenously) reduced myocardial infarct size by ∼50% when administered for… CONTINUE READING
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Infarct size after acute myocardial infarction measured by quantitative tomographic 99mtc Brown et al 131 at NATIONAL CHUNG HSING

  • TD Miller, TF Christian, MR Hopfenspirger, DO Hodge, BJ Gersh, RJ. Gibbons
  • UNIV on March
  • 2014
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