Reduction of dyskinesia and induction of akinesia induced by morphine in two Parkinsonian patients with severe sciatica

@article{Berg1999ReductionOD,
  title={Reduction of dyskinesia and induction of akinesia induced by morphine in two Parkinsonian patients with severe sciatica},
  author={D. Berg and Georg Becker and Karlheinz Reiners},
  journal={Journal of Neural Transmission},
  year={1999},
  volume={106},
  pages={725-728}
}
In two patients with Parkinson's disease and L-Dopa induced dyskinesia we administered morphine orally to alleviate lumboradicular pain unresponsive to any other form of treatment. Besides an alleviation of the pain both patients showed a decrease in dyskinetic movements at very low doses of morphine and an increase in akinesia at higher doses. This observation indicates a modulation of basal ganglia output by morphine with the possibility of reducing L-Dopa induced dyskinesia in patients… CONTINUE READING

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