Reduction of doxorubicin and oracin and induction of carbonyl reductase in human breast carcinoma MCF-7 cells.

@article{Gavelov2008ReductionOD,
  title={Reduction of doxorubicin and oracin and induction of carbonyl reductase in human breast carcinoma MCF-7 cells.},
  author={Martina Gavelov{\'a} and Jana Hlad{\'i}kov{\'a} and Lenka Vildov{\'a} and Romana Novotn{\'a} and Jan Vondr{\'a}{\vc}ek and Pavel Kr{\vc}m{\'a}ř and Miroslav Machala and Lenka Sk{\'a}lov{\'a}},
  journal={Chemico-biological interactions},
  year={2008},
  volume={176 1},
  pages={9-18}
}
In cancer cells, the drug-metabolizing enzymes may deactivate cytostatics, thus contributing to their survival. Moreover, the induction of these enzymes may also contribute to development of drug-resistance through acceleration of cytostatics deactivation. However, the principal metabolic pathways contributing to deactivation of many cytostatics still remain poorly defined. The main aims of the present study were: (i) to compare the reductive deactivation of cytostatic drugs doxorubicin (DOX… CONTINUE READING

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