Reduction of diphenyl diselenide and analogs by mammalian thioredoxin reductase is independent of their gluthathione peroxidase-like activity: a possible novel pathway for their antioxidant activity.

@article{Freitas2010ReductionOD,
  title={Reduction of diphenyl diselenide and analogs by mammalian thioredoxin reductase is independent of their gluthathione peroxidase-like activity: a possible novel pathway for their antioxidant activity.},
  author={Andressa Sausen de Freitas and Alessandro de Souza Prestes and Caroline Wagner and J{\'e}ssie Haigert Sudati and Diego Cardoso Alves and Lisiane Oliveira Porci{\'u}ncula and Ige Joseph Kade and Jo{\~a}o Batista Teixeira Rocha},
  journal={Molecules},
  year={2010},
  volume={15 11},
  pages={7699-714}
}
Since the successful use of the organoselenium drug ebselen in clinical trials for the treatment of neuropathological conditions associated with oxidative stress, there have been concerted efforts geared towards understanding the precise mechanism of action of ebselen and other organoselenium compounds, especially the diorganyl diselenides such as diphenyl… CONTINUE READING