• Corpus ID: 16993861

Reduction of dimesna to mesna by the isolated perfused rat liver.

@article{Goren1998ReductionOD,
  title={Reduction of dimesna to mesna by the isolated perfused rat liver.},
  author={Marshall P. Goren and Lichu Hsu and Jiang tao Li},
  journal={Cancer research},
  year={1998},
  volume={58 19},
  pages={
          4358-62
        }
}
Mesna is administered with ifosfamide and cyclophosphamide to reduce the incidence of hemorrhagic cystitis. In the present model of mesna metabolism and disposition, mesna is rapidly and irreversibly oxidized to dimesna in the plasma, passes unchanged through the liver, and is then reduced by the kidney and excreted. Our detection of a high ratio of mesna to dimesna in the plasma of clinical samples led us to reinvestigate the hepatic metabolism of mesna and dimesna. We perfused isolated rat… 
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