Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle

@article{Son2003ReductionOD,
  title={Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle},
  author={Cheol Hee Son and Dr. K. Hosoda and Keiichi Ishihara and Lisa Bevilacqua and Hiroaki Masuzaki and Tohru Fushiki and Maureen E. Harper and Kazuwa Nakao},
  journal={Diabetologia},
  year={2003},
  volume={47},
  pages={47-54}
}
It has been suggested that uncoupling protein 3 (UCP3) can increase energy expenditure, thereby regulating body weight. Although studies on UCP3 knock-out mice suggest that lack of UCP3 function does not cause obesity or Type 2 diabetes, it is possible that up-regulation of UCP3 function improves these disorders or their clinical sequelae. A 10- to 20-fold… CONTINUE READING