Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro.

@article{Coleman1993ReductionOD,
  title={Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro.},
  author={Michael D Coleman and David P. Jacobus},
  journal={Biochemical pharmacology},
  year={1993},
  volume={45 5},
  pages={1027-33}
}
The fate of the toxic metabolite of dapsone, dapsone hydroxylamine, has been studied in the human red cell. Twice-washed red cells were incubated at 37 degrees with dapsone hydroxylamine: at 3 and 5 min, 27.0 +/- 2.2 and 33.2 +/- 2.7% of the haemoglobin had been converted to methaemoglobin, leading to a maximum at 45 min (45 +/- 1.8%). HPLC analysis revealed that parent amine was produced from dapsone hydroxylamine during methaemoglobin formation in the red cells. At 3 min, conversion of… CONTINUE READING

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