Reduction of cytochrome-c oxidase copper precedes failing cerebral O2 utilization in fluorocarbon-perfused cats.

@article{Stingele1996ReductionOC,
  title={Reduction of cytochrome-c oxidase copper precedes failing cerebral O2 utilization in fluorocarbon-perfused cats.},
  author={Robert Stingele and Benedicht P. Wagner and Marina V. Kameneva and Michelle A. Williams and David A. H. Wilson and Nitish V. Thakor and Richard J. Traystman and Daniel F. Hanley},
  journal={The American journal of physiology},
  year={1996},
  volume={271 2 Pt 2},
  pages={H579-87}
}
We determined the relationship of the low-potential copper (CuA) redox state of cytochrome-c oxidase to the brain tissue PO2 (PtiO2) and global cerebral O2 consumption (CMRO2) in vivo. The redox state of cytochrome-c oxidase copper was monitored in perfluorocarbon-exchanged cats under normoxic and graded hypoxic conditions with use of near-infrared spectroscopy. Continuous spectra ranging from 730 to 960 nm were acquired, and the change in copper redox state was assessed by the absorption… CONTINUE READING