Reduction of cortical volume in schizophrenia on magnetic resonance imaging

  title={Reduction of cortical volume in schizophrenia on magnetic resonance imaging},
  author={Ian Harvey and Maria A. Ron and George H. du Boulay and D. A. G. Wicks and S. Lewis and Robin M. Murray},
  journal={Psychological Medicine},
  pages={591 - 604}
Synopsis The MRI scans of 48 schizophrenic patients, fulfilling RDC criteria, were compared to those of 34 healthy controls matched for age, ethnicity and parental social class. The volume of the frontal and anterior parietal lobes was significantly reduced in the schizophrenic group as a result of a selective decrease in cortical volume, with a corresponding increase in the volume of sulcal fluid. Reduction in the volume of the temporal grey matter was more marked on the right, but was not in… 

A profile of cortical gray matter volume deficits characteristic of schizophrenia.

The two schizophrenic groups displayed similar patterns of volume abnormalities: cortical gray matter but not white matter volume deficits that were widespread but especially notable in the prefrontal and temporal regions, which provide evidence for generality of this pattern of regional brain volume abnormalities in schizophrenia.

Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls

The authors' previous report of a significantly reduced cortical volume in the schizophrenic group, with a corresponding increase in the volume of sulcal fluid is, therefore, not a generalized feature of psychotic illness but may be more specific to schizophrenia.

Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms.

Anatomical abnormalities in these schizophrenic patients with marked negative symptoms were most evident in left hemispheric neocortical and limbic regions and related white matter tracts, compatible with models that depict schizophrenia as a supraregional disorder of multiple, distributed brain regions and the axonal connections between them.

Structural neuroimaging in schizophrenia

  • F. HennD. Braus
  • Psychology, Medicine
    European Archives of Psychiatry and Clinical Neuroscience
  • 1999
It is suggested that an integrative model with initial developmental errors may underlie the majority of cases of schizophrenia, but that cases of chronic schizophrenia appear to involve progressive neurodegeneration.

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Brain abnormalities in schizophrenia. A qualitative comparative study of schizophrenic patients and control individuals assessed by magnetic resonance imaging.

Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study




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Computed tomographic evidence for generalized sulcal and ventricular enlargement in schizophrenia.

The results show that the cerebral atrophy found in schizophrenia is diffuse in nature and does not relate clearly to measures of disease severity or chronicity.

Magnetic resonance imaging in schizophrenia. I. Volumetric analysis of brain and cerebrospinal fluid.

Although there was no gender x diagnosis interaction, the results for sulcal CSF were significant only for men, whereas for women, the ventricular ratios were marginally higher in patients, suggesting that anatomic changes reflected in CSF can provide a limited substrate for schizophrenia and may apply only to subpopulations.

Limbic structures and lateral ventricle in schizophrenia. A quantitative postmortem study.

Computer-assisted stereologic methods applied to serial coronal sections of complete hemispheres found no significant volume reduction of amygdala and hippocampal formation in schizophrenics, and methodologic issues of postmortem volumetric measurements and matching of samples are postulate.

A comprehensive study of chronic schizophrenic patients: I. Quantitative computed tomography: cerebral density, ventricle and sulcal measures

Although there were few differences between groups, there emerged a distinct subgroup of schizophrenic patients with mild lateral ventricle enlargement associated with increased cortical density, including the striking parallels with a recent neuropathological study's findings.